Widespread alterations in functional brain network architecture in amnestic mild cognitive impairment

Minati, Ludovico, Chan, Dennis, Mastropasqua, Chiara, Serra, Laura, Spanò, Barabara, Marra, Camillo, Caltagirone, Carlo, Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456 and Bozzali, Marco 2014. Widespread alterations in functional brain network architecture in amnestic mild cognitive impairment. Journal of Alzheimer's Disease 40 (1) , pp. 213-220. 10.3233/jad-131766

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Abstract

We investigated changes in functional network architecture in amnestic mild cognitive impairment using graph-based analysis of task-free functional magnetic resonance imaging and fine cortical parcellation. Widespread disconnection was observed primarily in cortical hubs known to manifest early Alzheimer's disease pathology, namely precuneus, parietal lobules, supramarginal and angular gyri, and cuneus, with additional involvement of subcortical regions, sensorimotor cortex and insula. The connectivity changes determined using graph-based analysis significantly exceed those detected using independent component analysis both in amplitude and topographical extent, and are largely decoupled from the presence of overt atrophy. This superior ability of graph-based analysis to detect disease-related disconnection highlights its potential use in the determination of biomarkers of early dementia. Graph-based analysis source code is provided as supplementary material.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	IOS Press
ISSN:	1387-2877
Date of Acceptance:	12 November 2013
Last Modified:	09 Nov 2022 10:27
URI:	https://orca.cardiff.ac.uk/id/eprint/139530

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