EPLIN expression in gastric cancer and impact on prognosis and chemoresistance

Gong, Wenjing, Zeng, Jianyuan, Ji, Jiafu, Jia, Yongning, Jia, Shuqin, Sanders, Andrew J. ORCID: https://orcid.org/0000-0002-7997-5286 and Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111 2021. EPLIN expression in gastric cancer and impact on prognosis and chemoresistance. Biomolecules 11 (4) , 547. 10.3390/biom11040547

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Abstract

Epithelial protein lost in neoplasm (EPLIN) has been implicated as a suppressor of cancer progression. The current study explored EPLIN expression in clinical gastric cancer and its association with chemotherapy resistance. EPLIN transcript expression, in conjunction with patient clinicopathological information and responsiveness to neoadjuvant chemotherapy (NAC), was explored in two gastric cancer cohorts collected from the Beijing Cancer Hospital. Kaplan-Meier survival analysis was undertaken to explore EPLIN association with patient survival. Reduced EPLIN expression was associated with significant or near significant reductions of overall, disease-free, first progression or post-progression survival in the larger host cohort and Kaplan Meier plotter datasets. In the larger cohort EPLIN expression was significantly higher in the combined T1 + T2 gastric cancer group compared to the T3 + T4 group and identified to be an independent prognostic factor of disease-free survival and overall survival by multivariate analysis. In the smaller, NAC cohort, EPLIN expression was found to be significantly lower in tumour tissues than in paratumour tissues. EPLIN expression was significantly associated with responsiveness to chemotherapy which contributes to overall survival. Together, EPLIN appears to be a prognostic factor and may be associated with patient sensitivity to NAC.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	MDPI
ISSN:	2218-273X
Funders:	The study was supported by the Cardiff University China Medical Scholarship, the Outstanding Young Scholarship from Yantai Yuhuangding Hospital.
Date of First Compliant Deposit:	8 April 2021
Date of Acceptance:	1 April 2021
Last Modified:	05 May 2023 23:32
URI:	https://orca.cardiff.ac.uk/id/eprint/140384

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