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Innate immunology in COVID-19?a living review. Part I: viral entry, sensing and evasion

Coveney, Clarissa, Tellier, Michel, Lu, Fangfang, Maleki Toyserkani, Shayda, Jones, Ruth, Bart, Valentina M. T., Pring, Ellie, Alrubayyi, Aljawharah, Richter, Felix C., Scourfield, D. Oliver, Rehwinkel, Jan, Rodrigues, Patrícia R. S., Davies, Luke C. and Gea-Mallorquí, Ester 2020. Innate immunology in COVID-19?a living review. Part I: viral entry, sensing and evasion. Oxford Open Immunology 1 (1) , iqaa004. 10.1093/oxfimm/iqaa004

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Abstract

The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and anti-viral treatments are still of vital importance, especially in context of the mutative ability of this group of viruses. Therefore, it is essential to elucidate the molecular mechanisms of viral entry, innate sensing and immune evasion of SARS-CoV-2, which control the triggers of the subsequent excessive inflammatory response. Viral evasion strategies directly target anti-viral immunity, counteracting host restriction factors and hijacking signalling pathways to interfere with interferon production. In Part I of this review, we examine SARS-CoV-2 viral entry and the described immune evasion mechanisms to provide a perspective on how the failure in initial viral sensing by infected cells can lead to immune dysregulation causing fatal COVID-19, discussed in Part II.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/)
ISSN: 2633-6960
Date of First Compliant Deposit: 28 April 2021
Date of Acceptance: 13 November 2020
Last Modified: 29 Apr 2021 10:00
URI: http://orca.cardiff.ac.uk/id/eprint/140828

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