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Spontaneous intracranial hypotension: features, diagnosis and management

Massey, Tom H. and Robertson, Neil P. 2021. Spontaneous intracranial hypotension: features, diagnosis and management. Journal of Neurology 268 (4) , pp. 1555-1557. 10.1007/s00415-021-10500-1

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Abstract

Spontaneous intracranial hypotension (SIH) is classically characterised by orthostatic headache and is commonly secondary to a spontaneous cerebrospinal fluid (CSF) leak near spinal nerve roots. Risk factors for SIH include connective tissue disorders, bariatric surgery and spinal pathologies such as osteophytes and disc prolapse. The annual incidence is approximately 1 in 20,000 individuals per year and the rarity of this condition has made large-scale studies of SIH difficult resulting in a limited evidence base for clinical decision-making. This month’s journal club examines three papers reporting on the presentation, investigation and treatment of SIH. The first is a large systematic review and meta-analysis of over 2000 SIH cases. The second reports on a case series of 44 patients with SIH secondary to a rare spinal structural abnormality: cerebrospinal fluid–venous fistula. The third provides clinical information on 29 patients with frontotemporal brain-sagging syndrome, a rare, but potentially reversible, complication of SIH.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Springer Verlag
ISSN: 0340-5354
Date of First Compliant Deposit: 14 May 2021
Date of Acceptance: 23 February 2021
Last Modified: 14 May 2021 13:00
URI: http://orca.cardiff.ac.uk/id/eprint/141313

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