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Base-mediated direct transformation of N-propargylamines into 2,3,5-trisubstituted 1 H-pyrroles

Mishra, Pawan K., Verma, Shalini, Kumar, Manoj and Verma, A.K. 2018. Base-mediated direct transformation of N-propargylamines into 2,3,5-trisubstituted 1 H-pyrroles. Organic Letters 20 (22) , pp. 7182-7185. 10.1021/acs.orglett.8b03112

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Abstract

An efficient and base-mediated intramolecular cyclization of N-propargylamines for the synthesis of structurally diversified pyrroles in high yield has been described. The developed methodology is broadly applicable and is tolerated by a variety of functional groups. Key intermediates of natural product discoipyrrole C as well as HMG-CoA-reductase inhibitor have been successfully synthesized using developed chemistry. The proposed mechanism was supported by control experiments.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: American Chemical Society
ISSN: 1523-7060
Last Modified: 25 May 2021 11:28
URI: http://orca.cardiff.ac.uk/id/eprint/141409

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