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Metal-free carbonyl-assisted regioselective hydration of alkynes: an access to dicarbonyls

Verma, S., Kumar, M., Mishra, P. K. and Verma, A. K. 2019. Metal-free carbonyl-assisted regioselective hydration of alkynes: an access to dicarbonyls. Organic Letters 21 (13) , pp. 5059-5063. 10.1021/acs.orglett.9b01649

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Abstract

Metal-free regioselective hydration of o-alkynylaldehydes with the assistance of neighboring carbonyl oxygen is disclosed. The developed protocol provides a facile route to synthesize a series of multisubstituted carbonyl containing scaffolds that enable the potential application toward the synthesis of highly diversified 5-azaindoles. γ-Carbolines and 2,8-diazacarbazoles can also be accessed directly without isolating the dicarbonyl compounds. The developed methodology is operationally simple and environment-friendly, tolerates a wide variety of functional groups, and is applicable toward large scale synthesis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: American Chemical Society
ISSN: 1523-7060
Last Modified: 25 May 2021 11:28
URI: http://orca.cardiff.ac.uk/id/eprint/141412

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