Innate and adaptive immune genes associated with MERS-CoV infection in dromedaries

Lado, Sara, Elbers, Jean P., Plasil, Martin, Loney, Tom, Weidinger, Pia, Camp, Jeremy V., Kolodziejek, Jolanta, Futas, Jan, Kannan, Dafalla A., Orozco-terWengel, Pablo ORCID: https://orcid.org/0000-0002-7951-4148, Horin, Petr, Nowotny, Norbert and Burger, Pamela A. 2021. Innate and adaptive immune genes associated with MERS-CoV infection in dromedaries. Cells 10 (6) , 1291. 10.3390/cells10061291

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Abstract

The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Publisher:	MDPI
ISSN:	2073-4409
Date of First Compliant Deposit:	21 June 2021
Date of Acceptance:	18 May 2021
Last Modified:	06 May 2023 03:53
URI:	https://orca.cardiff.ac.uk/id/eprint/142031

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