Synthesis and properties of novel chemiluminescent biological probes: substituted 4-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinium-9-carboxylate trifluoromethanesulphonate

Smith, Keith, Li, Zhaoqiang, Yang, Jing-Jing, Weeks, Ian ORCID: https://orcid.org/0000-0002-6362-2929 and Woodhead, J. Stuart 2000. Synthesis and properties of novel chemiluminescent biological probes: substituted 4-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinium-9-carboxylate trifluoromethanesulphonate. Journal of Photochemistry and Photobiology A: Chemistry 132 (3) , pp. 181-191. 10.1016/S1010-6030(00)00209-4

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Abstract

Substituted aryl acridinium esters, 2,6-dimethyl-4-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinium-9-carboxylate trifluoromethanesulphonate (3), 2,6-dimethoxy-4-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinium-9-carboxylate trifluoromethanesulphonate (4), 2-methoxy-4-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinium-9-carboxylate trifluoromethanesulphonate (5) and 2,6-dibromo-4-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinium-9-carboxylate trifluoromethanesulphonate (6), have been synthesised and coupled to immunoglobulinG(IgG). The chemiluminescent properties and hydrolytic stabilities of the conjugates have also been examined. The different substituents on the phenoxy ring affected the chemiluminescent efficiency and kinetics. All the human IgG conjugates of these substituted acridinium esters demonstrated much higher stability than the conjugate of the corresponding unsubstituted acridinium ester

Item Type:	Article
Status:	Published
Schools:	Chemistry Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	Acridinium ester; Chemiluminescence; Chemiluminescence immunoassay
Publisher:	Elsevier
ISSN:	1010-6030
Last Modified:	18 Oct 2022 13:32
URI:	https://orca.cardiff.ac.uk/id/eprint/14290

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