Attenuation of PITPNM1 signaling cascade can inhibit breast cancer progression

Liu, Zihao, Shi, Yu, Lin, Qun, Yang, Wenqian, Luo, Qing, Cen, Yinghuan, Li, Juanmei, Fang, Xiaolin, Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111 and Gong, Chang 2021. Attenuation of PITPNM1 signaling cascade can inhibit breast cancer progression. Biomolecules 11 (9) , 1265. 10.3390/biom11091265

PDF - Published Version Available under License Creative Commons Attribution. Download (2MB)

Abstract

Phosphatidylinositol transfer protein membrane-associated 1 (PITPNM1) contains a highly conserved phosphatidylinositol transfer domain which is involved in phosphoinositide trafficking and signaling transduction under physiological conditions. However, the functional role of PITPNM1 in cancer progression remains unknown. Here, by integrating datasets of The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer (METABRIC), we found that the expression of PITPNM1 is much higher in breast cancer tissues than in normal breast tissues, and a high expression of PITPNM1 predicts a poor prognosis for breast cancer patients. Through gene set variation analysis (GSEA) and gene ontology (GO) analysis, we found PITPNM1 is mainly associated with carcinogenesis and cell-to-cell signaling ontology. Silencing of PITPNM1, in vitro, significantly abrogates proliferation and colony formation of breast cancer cells. Collectively, PITPNM1 is an important prognostic indicator and a potential therapeutic target for breast cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	MDPI
ISSN:	2218-273X
Date of First Compliant Deposit:	1 September 2021
Date of Acceptance:	21 August 2021
Last Modified:	15 May 2023 02:35
URI:	https://orca.cardiff.ac.uk/id/eprint/143580

Citation Data

Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item