Measures of postural control and mobility during dual-tasking as candidate markers of instability in Huntington's Disease

Muratori, Lida M., Quinn, Lori ORCID: https://orcid.org/0000-0002-2982-923X, LI, Xueyao, Youdan, Gregory, Busse, Monica ORCID: https://orcid.org/0000-0002-5331-5909 and Fritz, Nora E. 2021. Measures of postural control and mobility during dual-tasking as candidate markers of instability in Huntington's Disease. Human Movement Science 80 , 102881. 10.1016/j.humov.2021.102881

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Abstract

Background Individuals with Huntington's disease (HD) have impairments in performing dual-tasks, however, there is limited information about the effects of changing postural and cognitive demands as well as which measures are best suited as markers of underlying motor-cognitive interference. Methods Forty-three individuals with HD and 15 healthy controls (HC) completed single tasks of walking (Timed Up & Go (TUG), 7 m walk), standing (feet together, feet apart and foam surface) and seated cognitive performance (Stroop, Symbol Digit Modalities Test (SDMT), Delis-Kaplan Executive Function System (DKEFS) Sorting test) and dual cognitive-motor tasks while standing (+ Stroop) and walking (+ DKEFS, TUG cognitive). APDM Opal sensors recorded measures of postural sway and time to complete motor tasks. Results Individuals with HD had a greater increase in standing postural sway compared to HC from single to dual-tasks and with changes to support surface. Both groups demonstrated a decrease in gait performance during the TUG cognitive, however, this difference was greater in people with HD compared to HC. While those with HD showed a greater dual-task motor cost compared to HC, both groups behaved similarly as condition complexity increased. Conclusions Standing postural sway is a more sensitive marker of instability than change in standard gait speed, particularly under dual-task conditions. The more complex TUG cognitive is a sensitive measure of walking dual-task performance. The results of this study provide insights about the nature of motor-cognitive impairments in HD and provide support for a distinction between static and dynamic postural control mechanisms during performance of dual-tasks.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Centre for Trials Research (CNTRR)
Publisher:	Elsevier
ISSN:	0167-9457
Funders:	Jacques and Gloria Gossweiler Foundation.
Date of First Compliant Deposit:	20 September 2021
Date of Acceptance:	17 September 2021
Last Modified:	09 Nov 2024 17:45
URI:	https://orca.cardiff.ac.uk/id/eprint/144285

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