Pharmacogenomics: A road ahead for precision medicine in psychiatry

Pardinas, Antonio F. ORCID: https://orcid.org/0000-0001-6845-7590, Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862 and Walters, James T.R. ORCID: https://orcid.org/0000-0002-6980-4053 2021. Pharmacogenomics: A road ahead for precision medicine in psychiatry. Neuron 109 (24) , pp. 3914-3929. 10.1016/j.neuron.2021.09.011

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Abstract

Psychiatric genomics is providing insights into the nature of psychiatric conditions that in time should identify new drug targets and improve patient care. Less attention has been paid to psychiatric pharmacogenomics research, despite its potential to deliver more rapid change in clinical practice and patient outcomes. The pharmacogenomics of treatment response encapsulates both pharmacokinetic (“what the body does to a drug”) and pharmacodynamic (“what the drug does to the body”) effects. Despite early optimism and substantial research in both these areas, they have to date made little impact on clinical management in psychiatry. A number of bottlenecks have hampered progress, including a lack of large-scale replication studies, inconsistencies in defining valid treatment outcomes across experiments, a failure to routinely incorporate adverse drug reactions and serum metabolite monitoring in study designs, and inadequate investment in the longitudinal data collections required to demonstrate clinical utility. Nonetheless, advances in genomics and health informatics present distinct opportunities for psychiatric pharmacogenomics to enter a new and productive phase of research discovery and translation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Cell Press
ISSN:	0896-6273
Date of First Compliant Deposit:	8 October 2021
Date of Acceptance:	9 September 2021
Last Modified:	07 Nov 2023 01:08
URI:	https://orca.cardiff.ac.uk/id/eprint/144751

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