Exciting new tools for studying TREM2 in dementia

Menzies, Georgina E. ORCID: https://orcid.org/0000-0002-6600-6507 and Torvell, Megan 2021. Exciting new tools for studying TREM2 in dementia. Structure 29 (11) , pp. 1215-1216. 10.1016/j.str.2021.10.009

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Abstract

TREM2 has long been implicated as an Alzheimer’s disease (AD) risk gene. In this issue of Structure, Szykowska et al., 2021 generate antibody single-chain variable fragments (scFvs) to the immunoglobulin(Ig)-like domain of human TREM2. They present two co-crystalized structures and characterize the functional impact of these scFvs on TREM2.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Schools > Biosciences
Publisher:	Elsevier
ISSN:	0969-2126
Last Modified:	06 Aug 2025 21:25
URI:	https://orca.cardiff.ac.uk/id/eprint/145301

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