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“Late-onset” ADHD symptoms in young adulthood: is this the same as child-onset ADHD?

Riglin, Lucy, Wootton, Robyn, Livingston, Lucy, Agnew-Blais, Jessica, Arseneault, Louise, Blakey, Rachel, Agha, Sharifah, Langley, Kate, Collishaw, Stephan, O'Donovan, Michael, Davey Smith, George, Stergiakouli, Evie, Tilling, Kate and Thapar, Anita 2022. “Late-onset” ADHD symptoms in young adulthood: is this the same as child-onset ADHD? Journal of Attention Disorders 10.1177/10870547211066486

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Abstract

Objective: We investigated whether “late-onset” ADHD that emerges in adolescence/adulthood is similar in risk factor profile to: (1) child-onset ADHD, but emerges later because of scaffolding/compensation from childhood resources; and (2) depression, because it typically onsets in adolescence/adulthood and shows symptom and genetic overlaps with ADHD. Methods: We examined associations between late-onset ADHD and ADHD risk factors, cognitive tasks, childhood resources and depression risk factors in a population-based cohort followed-up to age 25 years (N=4224–9764). Results: Parent-rated late-onset ADHD was like child-onset persistent ADHD in associations with ADHD polygenic risk scores and cognitive task performance, although self-rated late-onset ADHD was not. Late-onset ADHD was associated with higher levels of childhood resources than child-onset ADHD and did not show strong evidence of association with depression risk factors. Conclusions: Late-onset ADHD shares characteristics with child-onset ADHD when parent-rated, but differences for self-reports require investigation. Childhood resources may delay the onset of ADHD.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Medicine
Psychology
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: SAGE Publications
ISSN: 1087-0547
Date of First Compliant Deposit: 15 November 2021
Date of Acceptance: 14 November 2021
Last Modified: 24 Jan 2022 18:56
URI: http://orca.cardiff.ac.uk/id/eprint/145498

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