OC125 immunoscintigraphy in ovarian carcinoma: a comparison with alternative methods of assessment

Maughan, T. S., Haylock, B., Hayward, M., Facey, P., Evans, W. D. ORCID: https://orcid.org/0000-0003-0013-8205, Shelley, M. D., Fish, R. G. and Adams, M. 1990. OC125 immunoscintigraphy in ovarian carcinoma: a comparison with alternative methods of assessment. Clinical Oncology 2 (4) , pp. 199-205. 10.1016/s0936-6555(05)80168-2

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Abstract

The membrane bound, tumour associated antigen CA125 is recognized by the monoclonal antibody OC125 and may be detected in tumour tissue and serum in over 80% of patients with epithelial ovarian carcinomas. A total of 13 immunoscintigrams using 111 MBq 131I-OC125 have been performed in 11 patients. The results have been compared with clinical examination, CT and ultrasound scans, surgical findings and serum CA125 concentrations. Macroscopic disease was present at the time of scanning in 11 patients (<2 cm, eight patients, >2 cm, three patients). Clinical examination and ultrasound were positive in three, CT scanning in four, immunoscintography in seven and serum CA125 in eight patients. This pilot study suggests that serum CA125 estimation is the most sensitive indicator of disease activity. However, immunoscintigraphy using this agent may localize residual disease when clinical examination and other radiological investigations fail.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0936-6555
Date of Acceptance:	1 March 1990
Last Modified:	10 Nov 2022 10:11
URI:	https://orca.cardiff.ac.uk/id/eprint/145945

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