Oxygen levels are key to understanding “Anaerobic” protozoan pathogens with micro-aerophilic lifestyles

Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571, Chapman, Alan, Ellis, Jayne E., Hillman, Kevin, Paget, Timothy A., Yarlett, Nigel and Williams, Alan G. 2021. Oxygen levels are key to understanding “Anaerobic” protozoan pathogens with micro-aerophilic lifestyles. Advances in Microbial Physiology, Vol. 79. Elsevier, pp. 163-240. (10.1016/bs.ampbs.2021.09.001)

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Abstract

Publications abound on the physiology, biochemistry and molecular biology of “anaerobic” protozoal parasites as usually grown under “anaerobic” culture conditions. The media routinely used are poised at low redox potentials using techniques that remove O2 to “undetectable” levels in sealed containers. However there is growing understanding that these culture conditions do not faithfully resemble the O2 environments these organisms inhabit. Here we review for protists lacking oxidative energy metabolism, the oxygen cascade from atmospheric to intracellular concentrations and relevant methods of measurements of O2, some well-studied parasitic or symbiotic protozoan lifestyles, their homeodynamic metabolic and redox balances, organism-drug-oxygen interactions, and the present and future prospects for improved drugs and treatment regimes.

Item Type:	Book Section
Date Type:	Published Online
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISBN:	9780128246023
ISSN:	2211-3207
Date of Acceptance:	23 July 2020
Last Modified:	10 Nov 2022 10:13
URI:	https://orca.cardiff.ac.uk/id/eprint/146085

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