The mammillary bodies: a review of causes of injury in infants and children

Meys, Karlijn M.E., de Vries, Linda S., Groendaal, Floris, Vann, Seralynne D. ORCID: https://orcid.org/0000-0002-6709-8773 and Lequin, Maarten H. 2022. The mammillary bodies: a review of causes of injury in infants and children. American Journal of Neuroradiology 43 (6) , pp. 802-812. 10.3174/ajnr.A7463

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Abstract

SUMMARY: Despite their small size, the mammillary bodies play an important role in supporting recollective memory. However, they have typically been overlooked when assessing neurologic conditions that present with memory impairment. While there is increasing evidence of mammillary body involvement in a wide range of neurologic disorders in adults, very little attention has been given to infants and children. Literature searches of PubMed and EMBASE were performed to identify articles that describe mammillary body pathology on brain MR imaging in children. Mammillary body pathology is present in the pediatric population in several conditions, indicated by signal change and/or atrophy on MR imaging. The main causes of mammillary body pathology are thiamine deficiency, hypoxia-ischemia, direct damage due to masses or hydrocephalus, or deafferentation resulting from pathology within the wider Papez circuit. Optimizing scanning protocols and assessing mammillary body status as a standard procedure are critical, given their role in memory processes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	American Society of Neuroradiology
ISSN:	0195-6108
Date of First Compliant Deposit:	7 January 2022
Date of Acceptance:	22 November 2021
Last Modified:	24 Nov 2024 19:30
URI:	https://orca.cardiff.ac.uk/id/eprint/146452

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