Aligning cognitive studies in mouse models and human infants/toddlers: the case of Down Syndrome

D'Souza, Hana, Brady, Daniel, Wiseman, Frances K., Good, Mark A. ORCID: https://orcid.org/0000-0002-1824-1203 and Thomas, Michael S. C. 2021. Aligning cognitive studies in mouse models and human infants/toddlers: the case of Down Syndrome. Thomas, Michael S. C., Mareschal, Denis and Knowland, Victoria, eds. Taking Development Seriously A Festschrift for Annette Karmiloff-Smith: Neuroconstructivism and the multi-disciplinary approach to understanding the emergence of mind, Taylor and Francis, pp. 213-238.

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Abstract

This chapter provides an insight into Annette Karmiloff-Smith's thinking on her last project with the London Down Syndrome Consortium. It focuses on Annette’s interest in mouse modelling, as a further tool to help characterise atypical developmental mechanisms at multiple levels of description. London Down Syndrome Consortium is a large interdisciplinary collaboration between human geneticists, cellular biologists, psychiatrists, psychologists, neuroscientists and mouse geneticists, whose aim is to understand the link between Down syndrome and Alzheimer’s disease, and to identify protective and risk factors that could inform interventions. The mouse is a commonly used model organism in neurodevelopmental disorder research. Mouse models present an opportunity to test potential therapeutic interventions. The value of each mouse model of a neurodevelopmental disorder depends on two sorts of alignment: How well the genetics and physiology of the mouse align with the human; and How well the cognitive and behavioural phenotyping of the mouse maps to the human.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	Taylor and Francis
ISBN:	9781138334045
Last Modified:	10 Nov 2022 10:20
URI:	https://orca.cardiff.ac.uk/id/eprint/146499

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