Critical review of nanopillar-Based mechanobactericidal systems

Hawi, Sara, Goel, Saurav, Kumar, Vinod, Pearce, Oliver, Nishio Ayre, Wayne ORCID: https://orcid.org/0000-0003-2405-1876 and Ivanova, Elena P. 2022. Critical review of nanopillar-Based mechanobactericidal systems. ACS Applied Nano Material 5 (1) , pp. 1-17. 10.1021/acsanm.1c03045

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Abstract

The rise of multidrug-resistant bacteria is the biggest threat to human health globally, as described by the World Health Organization. Mechanobactericidal surfaces provide a sustainable approach to addressing this concern by eradicating pathogens, especially bacteria, “right-at-the-point” of contacting the surface. However, the lack of a “design to manufacture” approach due to our limited understanding of the mechanobactericidal mechanism has impeded engineering optimization to develop scalable exploitation routes in various healthcare applications. It can be argued that the reason, most particularly, is the limitations and uncertainties associated with the current instrumentation and simulation capabilities, which has led to several streams of test protocols. This review highlights the current understanding on the mechanobactericidal mechanisms in light of the contributing factors and various techniques that are used to postulate these mechanisms. The review offers a critique on the variations observed on how nanostructured surfaces found in the literature have been evaluated such that the test protocols and outcomes are incomparable. The review also shows a strong need for developing more accurate models of a bacterium because the currently reported experimental data are insufficient to develop bacterial material models (constitutive equations). The review also alludes to the scarcity of direct experimental evidence of the mechanobactericidal mechanism, suggesting a strong need for further in situ monitoring as a future research direction.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Publisher:	American Chemical Society
ISSN:	2574-0970
Date of First Compliant Deposit:	13 January 2022
Date of Acceptance:	20 December 2021
Last Modified:	15 Nov 2024 04:15
URI:	https://orca.cardiff.ac.uk/id/eprint/146508

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