Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-d-aspartate receptor allosteric modulators

Irvine, Mark W., Fang, Guangyu, Eaves, Richard, Mayo-Martin, Maria B., Burnell, Erica S., Costa, Blaise M., Culley, Georgia R., Volianskis, Arturas, Collingridge, Graham L., Monaghan, Daniel T. and Jane, David E. 2015. Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-d-aspartate receptor allosteric modulators. Synthesis 47 (11) , pp. 1593-1610. 10.1055/s-0034-1380114

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Abstract

9-Substituted phenanthrene-3-carboxylic acids have been reported to have allosteric modulatory activity at the N-methyl-d-aspartate (NMDA) receptor. This receptor is activated by the excitatory neurotransmitter l-glutamate and has been implicated in a range of neurological disorders such as schizophrenia, epilepsy and chronic pain, and in neurodegenerative disorders such as Alzheimer’s disease. Herein, the convenient synthesis of a wide range of novel 3,9-disubstituted phenanthrene derivatives starting from a few common intermediates is described. These new phenanthrene derivatives will help to clarify the structural requirements for allosteric modulation of the NMDA receptor.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	CC BY 4.0
Publisher:	Thieme Gruppe
ISSN:	0039-7881
Date of First Compliant Deposit:	9 February 2022
Date of Acceptance:	22 December 2014
Last Modified:	12 Jun 2023 22:30
URI:	https://orca.cardiff.ac.uk/id/eprint/146665

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