NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation

Park, Pojeong, Volianskis, Arturas, Sanderson, Thomas M., Bortolotto, Zuner A., Jane, David E., Zhuo, Min, Kaang, Bong-Kiun and Collingridge, Graham L. 2014. NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation. Philosophical Transactions of the Royal Society B: Biological Sciences 369 (1633) , 20130131. 10.1098/rstb.2013.0131

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Abstract

N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) is extensively studied since it is believed to use the same molecular mechanisms that are required for many forms of learning and memory. Unfortunately, many controversies exist, not least the seemingly simple issue concerning the locus of expression of LTP. Here, we review our recent work and some of the extensive literature on this topic and present new data that collectively suggest that LTP can be explained, during its first few hours, by the coexistence of at least three mechanistically distinct processes that are all triggered by the synaptic activation of NMDARs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited
Publisher:	The Royal Society
ISSN:	0962-8436
Date of First Compliant Deposit:	16 February 2022
Last Modified:	15 May 2023 10:41
URI:	https://orca.cardiff.ac.uk/id/eprint/146667

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