Subcutaneous Gammanorm® by pump or rapid push infusion: Impact of the device on quality of life in adult patients with primary immunodeficiencies

Warnatz, Klaus, Jolles, Stephen, Agostini, Carlo, Vianello, Fabrizio, Borte, Michael, Bethune, Claire, Grigoriadou, Sofia, Richter, Alex, Jain, Rashmi, Lowe, David M., Katelaris, Constance, Milito, Cinzia and Cook, Matthew C. 2022. Subcutaneous Gammanorm® by pump or rapid push infusion: Impact of the device on quality of life in adult patients with primary immunodeficiencies. Clinical Immunology 236 , 108938. 10.1016/j.clim.2022.108938

Full text not available from this repository.

Abstract

Many patients with immunodeficiencies require lifelong immunoglobulin replacement therapy (IgRT). In a multicenter, randomized, open-label, crossover, non-inferiority 3-month-trial, we compared the impact of the subcutaneous immunoglobulin Gammanorm® administered via pump or syringe (rapid push). Primary endpoint was the life quality index (LQI), secondary endpoints were QoL (SF36v2), satisfaction (TSQM-11), disease and treatment burden (PRISM), incidence of infections and adverse events (AE), treatment costs, and IgG levels. 28/30 patients completed the study. Most of the endpoints were comparable. Drug administrations with rapid push were more frequent, but reduced total time expenditure and some costs. Of the TSQM-11/LQI/SF36 components only “treatment interference with daily activities” was superior with pump and two QoL domains with rapid push. Both delivery devices showed favorable safety. Rapid push was preferred by 34.5% of patients. It proved to be an efficacious and cost-effective alternative to pumps adding to patient choice and increasing flexibility during long-term IgRT.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Academic Press
ISSN:	1521-6616
Funders:	N/A
Date of Acceptance:	26 January 2022
Last Modified:	22 Mar 2022 11:24
URI:	https://orca.cardiff.ac.uk/id/eprint/147231

Citation Data

Cited 1 time in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item