Distribution of P2X(3) receptors in the rat trigeminal ganglion after interior alveolar nerve injury

Eriksson, J., Bongenhielm, U., Kidd, Emma Jane ORCID: https://orcid.org/0000-0001-5507-1170, Matthews, T. and Fried, K. 1998. Distribution of P2X(3) receptors in the rat trigeminal ganglion after interior alveolar nerve injury. Neuroscience Letters 254 (1) , pp. 37-40. 10.1016/S0304-3940(98)00656-9

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Abstract

The ATP-gated cation channel receptor P2X3 is associated with nociceptive primary sensory neurons. We have, using immunohistochemistry, examined the expression of P2X3 in rat trigeminal ganglia 4–22 days after ligation/section or chronic constriction of the mandibular inferior alveolar nerve. In the normal trigeminal ganglion the anti-P2X3 receptor antibody labeled 37–58% of all neurons. Double labeling demonstrated that about 70–95% of the small neurons that bind the isolectin I-B4 displayed P2X3-immunoreactivity, and that about 40% of larger RT97-positive nerve cells were P2X3 receptor-immunoreactive. At 4 and 10 days after inferior alveolar nerve injury, the proportion of P2X3-immunoreactive neurons had increased to about 65% (range 52–78%). Examinations at the injury sites showed an intense P2X3 receptor-immunoreactivity in nerve endings. At longer survival stages the proportion of P2X3 receptor-positive sensory neurons had returned to control values. These results show that the P2X3 receptor is transiently upregulated and anterogradely transported in trigeminal primary sensory neurons after nerve injury. Since the receptor is accumulated in injured nerve endings, it may be associated with abnormal impulse propagation from these sites.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	P2X3 receptor; Trigeminal ganglion; Sensory neuron; Nerve injury; Immunohistochemistry; Pain
Publisher:	Elsevier
ISSN:	0304-3940
Last Modified:	18 Oct 2022 13:38
URI:	https://orca.cardiff.ac.uk/id/eprint/14748

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