Tortuosity assumption not the cause of NODDI’s incompatibility with tensor-valued diffusion encoding

Guerreri, Michele, Szczepankiewicz, Filip, Lampinen, Bjorn, Palombo, Marco ORCID: https://orcid.org/0000-0003-4892-7967, Nilsson, Markus and Zhang, Hui 2020. Tortuosity assumption not the cause of NODDI’s incompatibility with tensor-valued diffusion encoding. Presented at: ISMRM and SMRT Virtual Conference and Exhibition, Online, 8-14 August 2020.

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Abstract

This work shows that the tortuosity assumption in NODDI can not be identified as the source of incompatibility when the model is extended to data acquired with tensor-valued diffusion encoding. NODDI, originally developed for multi-shell linear tensor encoded (LTE) data, was shown to be inadequate when extended to LTE and spherical tensor encoded (STE) data jointly. The adoption of tortuosity assumption by NODDI has been suggested as a plausible explanation. We conduct a systematic model-comparison study to show that this explanation is inaccurate. We identify a different assumption of the model, the equal-axial-diffusivity, as a source of incompatibility.

Item Type:	Conference or Workshop Item - unpublished
Status:	Unpublished
Schools:	Schools > Psychology
Related URLs:	https://www.ismrm.org/20m/
Last Modified:	29 Oct 2026 10:45
URI:	https://orca.cardiff.ac.uk/id/eprint/147874

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