Improving strain diagnosis of prion disease by diffusion MRI and biophysical modelling

Palombo, Marco ORCID: https://orcid.org/0000-0003-4892-7967, Figin, Matteo, Pascuzzo, Riccardo, Caroppo, Paola, Verri, Mattia, Schneider, Torben, Gandini Wheeler-Kingshott, Claudia A. M., Redaelli, Veronica, Alexander, Daniel, Zhang, Hui, Giaccone, Giorgio and Bizzi, Alberto 2019. Improving strain diagnosis of prion disease by diffusion MRI and biophysical modelling. Presented at: 27th ISMRM Annual Meeting and Exhibition, 11-16 May 2019.

Full text not available from this repository.

Abstract

Sporadic Creutzfeldt–Jakob disease (sCJD) is the most common form of prion disease, characterized by five different strains, presenting intracellular vacuoles with different diameter/distribution. Unfortunately, no reliable non-invasive method for strain identification currently exists. Here we provide the first quantitative maps of MR-measured vacuolar diameter/density in five sCJD patients, using multishell diffusion MRI and biophysical modelling. Results show distribution of small and larger vacuoles in the brain lesions of each patient, presumably corresponding to different sCJD strains, and absence of vacuoles in five age-matched healthy controls. If validated, this method would be extremely valuable for non-invasive diagnosis of sCJD strain.

Item Type:	Conference or Workshop Item (Paper)
Status:	Unpublished
Schools:	Psychology
Last Modified:	07 Nov 2022 11:09
URI:	https://orca.cardiff.ac.uk/id/eprint/147880

Actions (repository staff only)

Edit Item