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Histological validation of the brain cell body imaging with diffusion MRI at ultrahigh field

Palombo, Marco ORCID: https://orcid.org/0000-0003-4892-7967, Nunes, Daniel, Alexander, Daniel C., Zhang, Hui and Shemesh, Noam 2019. Histological validation of the brain cell body imaging with diffusion MRI at ultrahigh field. Presented at: ISMRM 27th Annual Meeting and Exhibition, 11-16 May 2019. Published in: Port, J. D. and Noll, D. C. eds. Proceedings of the 27th ISMRM Annual Meeting and Exhibition. ISMRM (International Society for Magnetic Resonance in Medicine).

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Abstract

Biophysical modelling of diffusion-weighted MRI (DW-MRI) data can help to gain more insight into brain microstructure. However, models need to be validated. This work validates a recently-developed technique for non-invasive mapping of brain cell-body (soma) size/ density with DW-MRI, by using ultrahigh-field DW-MRI experiments and histology of mouse brain. Predictions from numerical simulations are experimentally confirmed and brain’s maps of MR-measured soma size/density are shown to correspond very well with histology. We provide differential contrasts between cell layers that are less expressed in tensor analyses, leading to novel complementary contrasts of the brain tissue. Limitations and future research directions are discussed.

Item Type: Conference or Workshop Item (Paper)
Status: Published
Schools: Psychology
Date of First Compliant Deposit: 20 May 2022
Date of Acceptance: 11 May 2019
Last Modified: 10 Nov 2022 10:42
URI: https://orca.cardiff.ac.uk/id/eprint/147882

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