New insight into the contrast in diffusional kurtosis images: does it depend on magnetic susceptibility?

Palombo, Marco ORCID: https://orcid.org/0000-0003-4892-7967, Gentili, Silvia, Bozzali, Marco, Macaluso, Emiliano and Capuani, Silvia 2015. New insight into the contrast in diffusional kurtosis images: does it depend on magnetic susceptibility? Magnetic Resonance in Medicine 73 (5) , pp. 2015-2024. 10.1002/mrm.25308

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Abstract

In this MRI study, diffusional kurtosis imaging (DKI) and T2* multiecho relaxometry were measured from the white matter (WM) of human brains and correlated with each other, with the aim of investigating the influence of magnetic-susceptibility (ΔχH2O-TISSUE) on the contrast. We focused our in vivo analysis on assessing the dependence of mean, axial, and radial kurtosis (MK, K‖, K⊥), as well as DTI indices on ΔχH2O-TISSUE (quantified by T2*) between extracellular water and WM tissue molecules. Moreover, Monte Carlo (MC) simulations were used to elucidate experimental data. A significant positive correlation was observed between K⊥, MK and R2* = 1/T2*, suggesting that ΔχH2O-TISSUE could be a source of DKI contrast. In this view, K⊥ and MK-map contrasts in human WM would not just be due to different restricted diffusion processes of compartmentalized water but also to local ΔχH2O-TISSUE. However, MC simulations show a strong dependence on microstructure rearrangement and a feeble dependence on ΔχH2O-TISSUE of DKI signal. Our results suggests a concomitant and complementary existence of multi-compartmentalized diffusion process and ΔχH2O-TISSUE in DKI contrast that might explain why kurtosis contrast is more sensitive than DTI in discriminating between different tissues. However, more realistic numerical simulations are needed to confirm this statement.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	Wiley
ISSN:	0740-3194
Date of Acceptance:	10 May 2014
Last Modified:	10 Nov 2022 10:43
URI:	https://orca.cardiff.ac.uk/id/eprint/147916

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