Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation-study on behalf of CMWP of the EBMT

Drozd-Sokołowska, Joanna, Gras, Luuk, Zinger, Nienke, Snowden, John A., Arat, Mutlu, Basak, Grzegorz, Pouli, Anastasia, Crawley, Charles, Wilson, Keith M. O., Tilly, Herve, Byrne, Jennifer, Bulabois, Claude Eric, Passweg, Jakob, Ozkurt, Zubeyde, Schroyens, Wilfried, Lioure, Bruno, Araujo, Mercedes Colorado, Poire, Xavier, Van Gorkom, Gwendolyn, Gurman, Gunham, de Wreede, Liesbeth C., Hayden, Patrick J., Beksac, Meral, Schonland, Stefan O. and Yakoub-Agha, Ibrahim 2022. Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation-study on behalf of CMWP of the EBMT. Bone Marrow Transplantation 57 , pp. 633-640. 10.1038/s41409-022-01592-y

PDF - Published Version Available under License Creative Commons Attribution. Download (766kB)

Abstract

Autologous hematopoietic cell transplantation (auto-HCT) may be performed in multiple myeloma (MM) patients relapsing after a previous auto-HCT. For those without an adequate dose of stored stem cells, remobilization is necessary. This retrospective study included patients who, following disease relapse after the first auto-HCT(s), underwent stem cell remobilization and auto-HCT performed using these cells. There were 305 patients, 68% male, median age at salvage auto-HCT was 59 years. The median time to relapse after the first-line penultimate auto-HCT(s) was 30.6 months, the median follow-up after salvage auto-HCT 31 months. The 2- and 4-year non-relapse mortality (NRM) after the salvage auto-HCT was 5 and 9%, the relapse incidence 56 and 76%, respectively. Overall survival (OS) after 2 and 4 years was 76 and 52%, progression-free survival (PFS) 39 and 15%. In multivariable analysis an increasing interval between the penultimate auto-HCT and relapse was associated with better OS and PFS, later calendar year of salvage auto-HCT with better OS. In conclusion, salvage auto-HCT performed with cells remobilized after a previous auto-HCT was associated with acceptable NRM. The leading cause of failure was disease progression of MM, which correlated with a shorter interval from the penultimate auto-HCT to the first relapse.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher:	Springer Nature
ISSN:	0268-3369
Date of First Compliant Deposit:	14 March 2022
Date of Acceptance:	19 January 2022
Last Modified:	02 May 2023 17:14
URI:	https://orca.cardiff.ac.uk/id/eprint/148088

Actions (repository staff only)

Edit Item