UK consensus statement on the use of plerixafor to facilitate autologous peripheral blood stem cell collection to support high-dose chemoradiotherapy for patients with malignancy

Douglas, Kenneth W., Gilleece, Maria, Hayden, Patrick, Hunter, Hannah, Johnson, Peter R. E., Kallmeyer, Charlotte, Malladi, Ram K., Paneesha, Shankara, Pawson, Rachel, Quinn, Michael, Raj, Kavita, Richardson, Deborah, Robinson, Stephen, Russell, Nigel, Snowden, John, Sureda, Anna, Tholouli, Eleni, Thomson, Kirsty, Watts, Mike and Wilson, Keith M. 2018. UK consensus statement on the use of plerixafor to facilitate autologous peripheral blood stem cell collection to support high-dose chemoradiotherapy for patients with malignancy. Journal of Clinical Apheresis 33 (1) , pp. 46-59. 10.1002/jca.21563

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Abstract

Plerixafor is a CXC chemokine receptor (CXCR4) antagonist that mobilizes stem cells in the peripheral blood. It is indicated (in combination with granulocyte-colony stimulating factor [G-CSF]) to enhance the harvest of adequate quantities of cluster differentiation (CD) 34+ cells for autologous transplantation in patients with lymphoma or multiple myeloma whose cells mobilize poorly. Strategies for use include delayed re-mobilization after a failed mobilization attempt with G-CSF, and rescue or pre-emptive mobilization in patients in whom mobilization with G-CSF is likely to fail. Pre-emptive use has the advantage that it avoids the need to re-schedule the transplant procedure, with its attendant inconvenience, quality-of-life issues for the patient and cost of additional admissions to the transplant unit. UK experience from 2 major centers suggests that pre-emptive plerixafor is associated with an incremental drug cost of less than £2000 when averaged over all patients undergoing peripheral blood stem cell (PBSC) transplant. A CD34+ cell count of <15 µl−1 at the time of recovery after chemomobilization or after four days of G-CSF treatment, or an apheresis yield of <1 × 106 CD34+ cells/kg on the first day of apheresis, could be used to predict the need for pre-emptive plerixafor.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley
ISSN:	0733-2459
Date of Acceptance:	31 May 2017
Last Modified:	27 Apr 2022 10:30
URI:	https://orca.cardiff.ac.uk/id/eprint/148096

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