The anterior thalamic nuclei: core components of a tripartite episodic memory system

Aggleton, John P. ORCID: https://orcid.org/0000-0002-5573-1308 and O’Mara, Shane M. 2022. The anterior thalamic nuclei: core components of a tripartite episodic memory system. Nature Reviews Neuroscience 23 , pp. 505-516. 10.1038/s41583-022-00591-8

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Abstract

Standard models of episodic memory focus on hippocampal–parahippocampal interactions, with the neocortex supplying sensory information and providing a final repository of mnemonic representations. However, recent advances have shown that other regions make distinct and equally critical contributions to memory. In particular, there is growing evidence that the anterior thalamic nuclei have a number of key cognitive functions that support episodic memory. In this article, we describe these findings and argue for a core, tripartite memory system, comprising a ‘temporal lobe’ stream (centred on the hippocampus) and a ‘medial diencephalic’ stream (centred on the anterior thalamic nuclei) that together act on shared cortical areas. We demonstrate how these distributed brain regions form complementary and necessary partnerships in episodic memory formation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	Nature Publishing Group
ISSN:	1471-003X
Date of First Compliant Deposit:	30 March 2022
Date of Acceptance:	25 March 2022
Last Modified:	06 Nov 2023 15:27
URI:	https://orca.cardiff.ac.uk/id/eprint/148986

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