Construction of complex memories via parallel distributed cortical-subcortical iterative integration

McNaughton, Neil and Vann, Seralynne D. ORCID: https://orcid.org/0000-0002-6709-8773 2022. Construction of complex memories via parallel distributed cortical-subcortical iterative integration. Trends in Neurosciences 45 (7) , pp. 550-562. 10.1016/j.tins.2022.04.006

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Abstract

The construction of complex engrams requires hippocampal–cortical interactions. These include both direct interactions and ones via often-overlooked subcortical loops. Here, we review the anatomical organization of a hierarchy of parallel ‘Papez’ loops through the hypothalamus that are homologous in mammals from rats to humans. These hypothalamic loops supplement direct hippocampal–cortical connections with iterative reprocessing paced by theta rhythmicity. We couple existing anatomy and lesion data with theory to propose that recirculation in these loops progressively enhances desired connections, while reducing interference from competing external goals and internal associations. This increases the signal-to-noise ratio in the distributed engrams (neocortical and cerebellar) necessary for complex learning and memory. The hypothalamic nodes provide key motivational input for engram enhancement during consolidation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Additional Information:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Publisher:	Cell Press
ISSN:	0166-2236
Funders:	Wellcome Trust
Date of First Compliant Deposit:	17 May 2022
Date of Acceptance:	22 April 2022
Last Modified:	07 Nov 2023 11:16
URI:	https://orca.cardiff.ac.uk/id/eprint/149790

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