Differentiation of Hebbian and homeostatic plasticity mechanisms within layer 5 visual cortex neurons

Pandey, Anurag, Hardingham, Neil and Fox, Kevin ORCID: https://orcid.org/0000-0002-2563-112X 2022. Differentiation of Hebbian and homeostatic plasticity mechanisms within layer 5 visual cortex neurons. Cell Reports 39 (9) , 110892. 10.1016/j.celrep.2022.110892

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Abstract

Cortical layer 5 contains two major types of projection neuron known as IB (intrinsic bursting) cells that project sub-cortically and RS (regular spiking) cells that project between cortical areas. This study describes the plasticity properties of RS and IB cells in the mouse visual cortex during the critical period for ocular dominance plasticity. We find that RS neurons exhibit synaptic depression in response to both dark exposure (DE) and monocular deprivation (MD), and their homeostatic recovery from depression is dependent on TNF-α. In contrast, IB cells demonstrate opposite responses to DE and MD, potentiating to DE and depressing to MD. IB cells’ potentiation depends on CaMKII-autophosphorylation and not TNF-α. IB cells show mature synaptic properties at the start of the critical period while RS cells mature during the critical period. Together with observations in somatosensory cortex, these results suggest that differences in RS and IB plasticity mechanisms are a general cortical property.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	User License Creative Commons Attribution (CC BY 4.0)
Publisher:	Cell Press
ISSN:	2211-1247
Funders:	MRC
Date of First Compliant Deposit:	1 June 2022
Date of Acceptance:	9 May 2022
Last Modified:	09 Apr 2024 16:12
URI:	https://orca.cardiff.ac.uk/id/eprint/150174

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