Patients' experiences of cancer immunotherapy with immune checkpoint inhibitors: a systematic review and qualitative evidence synthesis

Watts, Tessa ORCID: https://orcid.org/0000-0002-1201-5192, Csontos, Judit ORCID: https://orcid.org/0000-0003-4597-3052, Roche, Dominic and Jennings, Stephen 2022. Patients' experiences of cancer immunotherapy with immune checkpoint inhibitors: a systematic review and qualitative evidence synthesis. Presented at: RCN International Nursing Research Conference, Cardiff, UK, 5-6 September 2022.

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Abstract

Background Immune checkpoint inhibitors (ICIs) constitute one of the most successful developments in treatments for certain cancer types in recent years, transforming survival outcomes for many with advanced disease. However, the potentially prolonged nature of treatment coupled with the possibility of unique immune-related adverse events means there is potential for a substantial burden of treatment impacting on individual’s lives. Understanding patients’ experiences of ICIs is crucial to identify their support needs and provide person-centred care. Aim To explore patients’ experiences of cancer ICIs through a qualitative evidence synthesis (PROSPERO registered: CRD42021261634). Method Five electronic databases were searched (MEDLINE, CINAHL, PsycINFO, Embase, Web of Science) from 2010 until January 2022 using MeSH and text-word terms for cancer, immunotherapy, ICIs and qualitative research filters. Retrieved records were screened by two reviewers independently, with conflicts resolved by a third person. Relevant data were extracted from full-text papers and the quality of included papers was assessed with Critical Appraisal Skills Programme Checklist (CASP). Thematic synthesis methods were used to combine primary study findings. Results The searches identified 1318 records and following duplicate removal, 1022 unique entries were screened resulting in 34 full-text papers being further examined. Included research methodologies were qualitative and mixed methods studies, with data mainly collected via in-depth interviews or focus groups. Common themes were: hope for ICI as a medical innovation; side effects’ impact on quality of life; uncertainty; and the psychological impact of cancer diagnosis and treatments, information and supportive care needs. Discussion and Conclusion While ICIs were often perceived positively by patients, providing hope and potential for prolonged survival, there were numerous unmet needs identified particularly regarding information, psychological, and practical support. Healthcare professionals need to make sure that information about side effects and cancer prognosis is clearly communicated and support is available for patients with unmet needs.

Item Type:	Conference or Workshop Item - unpublished
Date Type:	Publication
Status:	Unpublished
Schools:	Schools > Healthcare Sciences
Funders:	Macmillan Cancer Support
Projects:	Experiences of Cancer Immunotherapy with Immune Checkpoint Inhibitors
Last Modified:	21 Oct 2026 11:20
URI:	https://orca.cardiff.ac.uk/id/eprint/152453

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