Signalling pathways involved in ribonuclease-7 expression

Mohammed, Imran ORCID: https://orcid.org/0000-0002-8412-0768, Yeung, Aaron, Abedin, Asiya, Hopkinson, Andrew and Dua, Harminder S. 2011. Signalling pathways involved in ribonuclease-7 expression. Cellular and Molecular Life Sciences 68 (11) , pp. 1941-1952. 10.1007/s00018-010-0540-2

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Abstract

Antimicrobial peptides are host defence molecules that play a potential role in preventing infection at the epithelial surfaces. Ribonuclease (RNase)-7 has been shown to possess a broad spectrum of microbicidal activity against various pathogens. Here, we demonstrate that RNase-7 protein is localised to the superficial layers of ocular surface cells and increased in response to interleukin (IL)-1β, suggesting an active role during inflammation related to ocular surface infection. Signal transduction pathways involved in RNase-7 expression are unknown. Involvement of transforming growth factor β-activated kinase-1 (TAK-1) activated nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathway molecules [c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38] were studied because of their importance in infection and inflammation. Blocking the MAPKs resulted in inhibition of RNase-7 expression in response to IL-1β. However, RNase-7 induction by IL-1β was not affected by inhibiting the NF-κB signalling pathway. In conclusion, our results indicate that RNase-7 expression is specifically mediated via MAPKs but not NF-κB signalling pathways.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Optometry and Vision Sciences
Publisher:	Springer
ISSN:	1420-682X
Date of Acceptance:	22 September 2010
Last Modified:	11 Nov 2022 09:02
URI:	https://orca.cardiff.ac.uk/id/eprint/152701

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