The interindividual variability of multimodal brain connectivity maintains spatial heterogeneity and relates to tissue microstructure

Karahan, Esin, Tait, Luke, Si, Ruoguang ORCID: https://orcid.org/0000-0001-6253-6351, Ozkan, Aysegul, Szul, Maciek J., Graham, Kim S., Lawrence, Andrew D. ORCID: https://orcid.org/0000-0001-6705-2110 and Zhang, Jiaxiang ORCID: https://orcid.org/0000-0002-4758-0394 2022. The interindividual variability of multimodal brain connectivity maintains spatial heterogeneity and relates to tissue microstructure. Communications Biology 5 , 1007. 10.1038/s42003-022-03974-w

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Abstract

Humans differ from each other in a wide range of biometrics, but to what extent brain connectivity varies between individuals remains largely unknown. By combining diffusion-weighted imaging (DWI) and magnetoencephalography (MEG), this study characterizes the inter-subject variability (ISV) of multimodal brain connectivity. Structural connectivity is characterized by higher ISV in association cortices including the core multiple-demand network and lower ISV in the sensorimotor cortex. MEG ISV exhibits frequency-dependent signatures, and the extent of MEG ISV is consistent with that of structural connectivity ISV in selective macroscopic cortical clusters. Across the cortex, the ISVs of structural connectivity and beta-band MEG functional connectivity are negatively associated with cortical myelin content indexed by the quantitative T1 relaxation rate measured by high-resolution 7 T MRI. Furthermore, MEG ISV from alpha to gamma bands relates to the hindrance and restriction of the white-matter tissue estimated by DWI microstructural models. Our findings depict the inter-relationship between the ISV of brain connectivity from multiple modalities, and highlight the role of tissue microstructure underpinning the ISV.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Advanced Research Computing @ Cardiff (ARCCA) Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Publisher:	Nature Research
Funders:	Wellcome Trust, MRC, BBSRC
Date of First Compliant Deposit:	21 September 2022
Date of Acceptance:	9 September 2022
Last Modified:	14 Jun 2024 15:52
URI:	https://orca.cardiff.ac.uk/id/eprint/152768

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