Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites

Petrova, Yoana D and Mahenthiralingam, Eshwar ORCID: https://orcid.org/0000-0001-9014-3790 2022. Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites. The Cell Surface 8 , 100081. 10.1016/.tcsw.2022.10081

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Abstract

Burkholderia sensu lato bacteria have genomes rich in biosynthetic gene clusters (BGCs) encoding for multiple bioactive specialised metabolites. Diverse classes of antimicrobial natural products have been isolated from Burkholderia, including polyynes, shikimate pathway derivatives, polyketides, non-ribosomal peptides and hybrid polyketide non-ribosomal peptides. We highlight examples of Burkholderia metabolites, overviewing their biosynthesis, bioactivity, mechanisms of action and secretion.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Date of First Compliant Deposit:	18 October 2022
Date of Acceptance:	12 October 2022
Last Modified:	26 May 2023 06:29
URI:	https://orca.cardiff.ac.uk/id/eprint/153491

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