Dias, Luiz C., Gonzaga De Oliveira, Luciana and de Sousa, Márcio A. 2003. Total synthesis of (−)-pironetin. Organic Letters 5 (3) , pp. 265-268. 10.1021/ol027211o |
Official URL: http://dx.doi.org/10.1021/ol027211o
Abstract
The asymmetric total synthesis of pironetin, a compound that shows plant growth regulatory activity, immunosuppressive as well as a remarkable antitumoral activity, is described. The approach involves the use of three very efficient Evans oxazolidinone-mediated syn-aldol condensations, a high-yielding coupling between lithium acetylide ethylenediamine complex and a tosylate followed by methylation, and selective reduction to establish the C12−C13 (E) double bond.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Publisher: | American Chemical Society |
ISSN: | 1523-7060 |
Last Modified: | 14 Nov 2022 16:04 |
URI: | https://orca.cardiff.ac.uk/id/eprint/153685 |
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