Cover picture: new cyclodepsipeptide derivatives revealed by genome mining and molecular networking (27/2019)

Paulo, Bruno S., Sigrist, Renata, Angolini, Célio F. F. and Gonzaga De Oliveira, Luciana 2019. Cover picture: new cyclodepsipeptide derivatives revealed by genome mining and molecular networking (27/2019). ChemistrySelect 4 (27) , p. 7784. 10.1002/slct.201902252

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Abstract

The cover picture shows a graphic illustration of a DNA being “mined” for encoding genes that combined comprise the minimal information to architect a molecule or group of molecules produced as secondary metabolite in a wild type strain or in a heterologous host when the whole pathway machinery is transported. The genes represented by arrows and codifying VLM1 and VLM2 giant proteins' interconnect four modules with high versatility to produce cyclodepsipeptides. Combining molecular networking analysis as dereplication tool (on top) unraveled new cyclodepsipeptide derivatives produced by valinomycin biosynthetic pathway. More information can be found in the Communication by De Oliveira et. al (DOI: 10.1002/slct.201900922). Artwork by C. F. F. Angolini

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Wiley
ISSN:	2365-6549
Last Modified:	14 Nov 2022 16:06
URI:	https://orca.cardiff.ac.uk/id/eprint/153711

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