Clusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study

Laucyte-Cibulskiene, Agne, Chen, Chen-Huan, Cockroft, John, Cunha, Pedro G., Kavousi, Maryam, Laucevicius, Aleksandras, Muiesan, Maria Lorenza, Rietzschel, Ernst R., Ryliskyte, Ligita, Strazhesko, Irina D., Vlachopoulos, Charalambos, Cotter, Jorge, Dudinskaya, Ekatherina N., Gale, Nichola ORCID: https://orcid.org/0000-0001-5207-9863, Ahmadizar, Fariba, Mattace-Raso, Francesco U. S., Munnery, Maggie, Oliveira, Pedro, Paini, Anna, Salvetti, Massimo, Tkacheva, Olga N., Lakatta, Edward G., Nilsson, Peter M. and Scuteri, Angelo 2022. Clusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study. Scientific Reports 12 (1) , 14409. 10.1038/s41598-022-18094-y

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Abstract

The effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on CBP in a large population and to identify whether this effect differs in men and women. We studied 15,609 volunteers (43% women) from 10 cohorts worldwide who participated in the Metabolic syndrome and Artery REsearch Consortium. MetS was defined according to the NCEP-ATP III criteria (GHTBW, glucose, high-density lipoprotein cholesterol, triglyceride, blood pressure, waist circumference). CBP was measured noninvasively and acquired from pulse wave analysis by applanation tonometry. MetS was associated with a 50% greater odds of having higher CSBP. After controlling for age, male sex, non HDL cholesterol, diabetes mellitus, and mean arterial pressure, only specific clusters of MetS components were associated with a higher CSBP; and some of them were significant in women but not in men. We identified “risky clusters” of MetS variables associated with high CSBP. Future studies are needed to confirm they identify subjects at high risk of accelerated arterial aging and, thus, need more intensive clinical management.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Healthcare Sciences
Publisher:	Nature Research
ISSN:	2045-2322
Date of First Compliant Deposit:	26 October 2022
Date of Acceptance:	5 August 2022
Last Modified:	29 Jun 2023 08:33
URI:	https://orca.cardiff.ac.uk/id/eprint/153797

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