Sleep disorders in Parkinson’s disease

Hawken, Jonathan and Robertson, Neil ORCID: https://orcid.org/0000-0002-5409-4909 2022. Sleep disorders in Parkinson’s disease. Journal of Neurology 269 , pp. 6685-6687. 10.1007/s00415-022-11403-5

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Abstract

Parkinson’s Disease (PD) is a neurodegenerative disorder characterised by motor and non-motor features. Sleep disruption, including REM-sleep behaviour disorder and circadian rhythm dysfunction, is a well-recognised prodromal aspect of PD, although other features such as restless leg syndrome and other physical factors may contribute. Treatment of PD remains challenging due to the multifactorial nature of the disorder and requires a holistic approach. Improved understanding of central causes may be key to developing novel, effective and targeted treatments. In this month’s journal club, we first review the association between alpha-synuclein in CSF and sleep disorders in prodromal and established PD. Secondly, we explore the role of Diffusion Tensor Imaging in assessing the glymphatic system in a similar cohort comparison. Finally, we will appraise the efficacy of Nabilone as a possible new therapeutic option for sleep disturbance in patients with established PD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	Springer
ISSN:	0340-5354
Date of First Compliant Deposit:	31 October 2022
Date of Acceptance:	23 September 2022
Last Modified:	01 Jun 2023 08:15
URI:	https://orca.cardiff.ac.uk/id/eprint/153860

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