Enantioselective applications of frustrated Lewis pairs in organic synthesis

Guerzoni, Michael G., Dasgupta, Ayan, Richards, Emma ORCID: https://orcid.org/0000-0001-6691-2377 and Melen, Rebecca L. ORCID: https://orcid.org/0000-0003-3142-2831 2022. Enantioselective applications of frustrated Lewis pairs in organic synthesis. Chem Catalysis 2 (11) , pp. 2865-2875. 10.1016/j.checat.2022.09.007

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Abstract

The field of asymmetric catalysis has witnessed tremendous development since its discovery, and this has recently culminated in the Nobel prize given to Benjamin List and David MacMillan “for the development of asymmetric organocatalysis.” In this perspective, we aim to highlight a less-represented class of catalysts, which can be also employed in enantioselective transformations: cooperative main-group Lewis acids and Lewis bases. Since 2007, this concept has been strongly associated with the term frustrated Lewis pair (“FLP”). Chiral FLPs have been applied in hydrogenation reactions whereby the enantioselective transformation is accomplished by using an FLP containing either a chiral Lewis acid or a chiral Lewis base. Chiral intramolecular FLPs have also been employed for this purpose. This perspective will look at the recent developments in enantioselective FLP catalysis and will suggest new directions for the field, taking inspiration from the ongoing research in the area of enantioselective cooperative catalysis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Publisher:	Cell Press
ISSN:	2667-1093
Funders:	Leverhulme Trust
Date of First Compliant Deposit:	8 December 2022
Date of Acceptance:	29 September 2022
Last Modified:	08 Nov 2024 00:30
URI:	https://orca.cardiff.ac.uk/id/eprint/154755

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