Transglutaminase-4 (prostate transglutaminase), a potential biological factor and clinical indicator for the diagnosis and prognosis of prostate cancer

Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409, Sanders, Andrew J. ORCID: https://orcid.org/0000-0002-7997-5286 and Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111 2023. Transglutaminase-4 (prostate transglutaminase), a potential biological factor and clinical indicator for the diagnosis and prognosis of prostate cancer. Anticancer Research 43 (1) , pp. 291-296. 10.21873/anticanres.16162

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (709kB) | Preview

Abstract

Transglutaminase-4, also known as prostate transglutaminase, is a protein encoded by the TGM4 gene. TGase-4 was thought to be exclusively expressed in the prostate gland and has been suggested to be involved in certain medical conditions, such as infertility and possibly prostate cancer. In recent years, substantial progress has been made in the understanding of this unique protein in prostate cancer, with emerging clinical evidence. The present concise review summarised the current understanding of this intriguing enzyme in prostate cancer and presents an argument that TGase-4 is a useful indicator of both the development and progression of the disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	International Institute of Anticancer Research
ISSN:	1791-7530
Date of First Compliant Deposit:	4 January 2023
Date of Acceptance:	26 October 2022
Last Modified:	04 May 2023 18:22
URI:	https://orca.cardiff.ac.uk/id/eprint/155288

Actions (repository staff only)

Edit Item