The bio-tribological properties of anti-adhesive agents commonly used during tendon repair

McGonagle, Lorcan John, Jones, Michael David ORCID: https://orcid.org/0000-0002-6058-6029, Dowson, Duncan and Theobald, Peter ORCID: https://orcid.org/0000-0002-3227-7130 2012. The bio-tribological properties of anti-adhesive agents commonly used during tendon repair. Journal of Orthopaedic Research 30 (5) , pp. 775-780. 10.1002/jor.21569

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Abstract

Frictional resistance to tendon gliding is minimized by surrounding loose areolar tissue. During periods of prolonged immobilization, for example, post-tendon-repair, adhesions can form between these two adjacent tissues, thereby limiting tendon function. Anti-adhesive agents can be applied during surgery to prevent adhesion formation, whilst reportedly providing some reduction in friction during in vitro tendon-bony pulley investigations. This bio-tribological study evaluates whether application of these agents can improve the lubrication between the tendon and surrounding tissue, thus potentially reducing the risk of re-rupturing the tendon at the repair site. The use of bovine synovial fluid (BSF) enabled an approximation of the in vivo lubrication regime, and subsequent comparison of the performance of three synthetic agents (50 mg/ml 5-fluorouracil; 5 mg/ml hyaluronic acid; ADCON–T/N). Coefficient of friction data was recorded and then compared with the Stribeck curve. BSF generated a fluid film that separated the two surfaces, giving rise to optimal lubrication conditions. This efficient regime was also generated following application of each anti-adhesion agent. The use of phosphate-buffered saline solution in generating only a boundary lubrication regime highlighted the effectiveness of the agents in reducing friction. Hyaluronic acid (5 mg/ml) was marginally deemed the most effective anti-adhesive agent at lubricating the tendon. Subsequently, it is concluded that the application of anti-adhesive agents post-surgery has secondary, tribological benefits that serve to reduce friction, and thus potentially the risk of failure, at the tendon repair site.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Centre for Advanced Manufacturing Systems At Cardiff (CAMSAC) Engineering
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	adhesion; biotribology; failure; repair; tendon
Publisher:	Wiley
ISSN:	0736-0266
Last Modified:	18 Oct 2022 13:49
URI:	https://orca.cardiff.ac.uk/id/eprint/15545

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