Interdependence of primary and secondary somatosensory cortices for plasticity and texture discrimination learning

Pandey, Anurag, Kang, Sungmin ORCID: https://orcid.org/0000-0002-7442-4143, Pacchiarini, Nicole ORCID: https://orcid.org/0000-0001-5383-6053, Wyszynska, Hanna, Grewal, Aneesha, Griffiths, Alex, Healy-Millett, Imogen, Masseri, Zena, Hardingham, Neil, O'Neill, Joseph ORCID: https://orcid.org/0000-0003-1886-8476, Honey, Rob ORCID: https://orcid.org/0000-0001-6870-1880 and Fox, Kevin ORCID: https://orcid.org/0000-0002-2563-112X 2023. Interdependence of primary and secondary somatosensory cortices for plasticity and texture discrimination learning. [Online]. BioXiv. Available at: https://www.biorxiv.org/content/10.1101/2023.04.25...

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Abstract

Feedforward and feedback pathways are important for transfer and integration of information between sensory cortical areas. Here we find that two closely connected cortical areas, the primary (S1) and secondary somatosensory cortices (S2) are both required for mice to learn a whisker-dependent texture discrimination. Increased inhibition in either area (using excitatory DREADDs expressed in inhibitory interneurones) prevents learning. We find that learning the discrimination produces structural plasticity of dendritic spines on layer 2/3 pyramidal neurones in vibrissae S1 that is restricted to the basal dendrites and leaves dendritic spines on apical dendrites unchanged. As S2 projects to the apical dendrites of S1 neurones, we tested whether S2 affects LTP-induction in S1. We found that feedback projections from S2 to S1 gates LTP on feedforward pathways within S1. These studies therefore demonstrate the interdependence of S1 and S2 for learning and plasticity in S1.

Item Type:	Website Content
Date Type:	Publication
Status:	Published
Schools:	Psychology Biosciences
Publisher:	BioXiv
Date of First Compliant Deposit:	5 May 2023
Date of Acceptance:	25 April 2023
Last Modified:	25 May 2023 13:27
URI:	https://orca.cardiff.ac.uk/id/eprint/159245

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