Modelling polarity-driven laminar patterns in bilayer tissues with mixed signalling mechanisms

Moore, Joshua W., Dale, Trevor C. ORCID: https://orcid.org/0000-0002-4880-9963 and Woolley, Thomas E. ORCID: https://orcid.org/0000-0001-6225-5365 2023. Modelling polarity-driven laminar patterns in bilayer tissues with mixed signalling mechanisms. SIAM Journal on Applied Dynamical Systems 22 (4) , pp. 2945-2990. 10.1137/22M1522565

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Abstract

Recent advances in high-resolution experimental methods have highlighted the significance of cell signal pathway crosstalk and localised signalling activity in the development and disease of numerous biological systems. The investigation of multiple signal pathways often introduces different methods of cell-cell communication, i.e. contact-based or diffusive signalling, which generates both a spatial and temporal dependence on cell behaviours. Motivated by cellular mechanisms that control cell-fate decisions in developing bilayer tissues, we use dynamical systems coupled with multilayer graphs to analyse the role of signalling polarity and pathway crosstalk in fine-grain pattern formation of protein activity. Specifically, we study how multilayer graph edge structures and weights influence the layer-wise (laminar) patterning of cells in bilayer structures, which are commonly found in glandular tissues. We present sufficient conditions for existence, uniqueness and instability of homogeneous cell states in the large-scale spatially discrete dynamical system. Using methods of pattern templating by graph partitioning to generate quotient systems, in combination with concepts from monotone dynamical systems, we exploit the extensive dimensionality reduction to provide existence conditions for the polarity required to induce fine-grain laminar patterns with multiple spatially dependent intracellular components. We then explore the spectral links between the quotient and large-scale dynamical systems to extend the laminar patterning criteria from existence to convergence for sufficiently large amounts of cellular polarity in the large-scale dynamical system, independent of spatial dimension and number of cells in the tissue.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI) Mathematics
Publisher:	Society for Industrial and Applied Mathematics
ISSN:	1536-0040
Date of First Compliant Deposit:	6 June 2023
Date of Acceptance:	2 June 2023
Last Modified:	08 Nov 2023 04:56
URI:	https://orca.cardiff.ac.uk/id/eprint/160203

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