Genetic risk and familial transmission of depression

Forty, Liz, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211 and Craddock, Nick 2008. Genetic risk and familial transmission of depression. Dobson, Keith S. and Dozois, David J.A., eds. Risk Factors for Depression, Elsevier, pp. 19-35. (10.1016/B978-0-08-045078-0.00002-2)

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Abstract

There are not always clear triggers for an episode of depression, and some individuals appear to be more susceptible than others to suffering with depression. In some cases, depression may run in the family. There is now substantial support for the notion that there is an inherited component to most cases of depression, which is the result of susceptibility genes that are passed down from parents to children. This chapter examines depressive episodes that occur in the context of a unipolar affective disorder. Depressive episodes are a prominent feature in bipolar affective disorder. The diagnosis of bipolar disorder, however, requires that an individual has suffered one or more episodes of mania with or without episodes of depression at other times during the life history, and it is the occurrence of mania which distinguishes bipolar from unipolar disorder, in which individuals suffer one or more episodes of depression without ever experiencing episodes of pathologically elevated mood.

Item Type:	Book Section
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISBN:	9780080560564
Last Modified:	29 Aug 2023 14:00
URI:	https://orca.cardiff.ac.uk/id/eprint/160400

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