Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer

Schneider, Johannes Josef, Faggian, Alessia, Jamieson, William David, Weyland, Mathias Sebastian, Li, Jin ORCID: https://orcid.org/0000-0002-4672-6806, Castell, Oliver ORCID: https://orcid.org/0000-0002-6059-8062, Matuttis, Hans-Georg, Barrow, David Anthony ORCID: https://orcid.org/0000-0003-2096-7262, Diaz, Aitor Patiño, Sanahuja, Lorena Cebolla, Holler, Silvia, Casiraghi, Federica, Hanczyc, Martin Michael, Flumini, Dandolo, Eggenberger Hotz, Peter and Füchslin, Rudolf Marcel 2023. Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation, Gaeta, Italy, 14-16 September 2022. Published in: De Stefano, C., Fontanella, F. and Vanneschi, L. eds. WIVACE 2022. Artificial Life and Evolutionary Computation. Communications in Computer and Information Science , vol.1780 Cham, Switzerland: Springer, pp. 107-118. 10.1007/978-3-031-31183-3_9

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Abstract

Within the scope of the European Horizon 2020 project ACDC – Artificial Cells with Distributed Cores to Decipher Protein Function, we aim at the development of a chemical compiler governing the three-dimensional arrangement of droplets, which are filled with various chemicals. Neighboring droplets form bilayers with pores which allow chemicals to move from one droplet to its neighbors. With an appropriate three-dimensional configuration of droplets, we can thus enable gradual biochemical reaction schemes for various purposes, e.g., for the production of macromolecules for pharmaceutical purposes. In this paper, we demonstrate with artificial chemistry simulations that the ACDC technology is excellently suitable to maximize the yield of desired reaction products or to minimize the relative output of unwanted side products.

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Publication
Status:	Published
Schools:	Engineering Pharmacy
Publisher:	Springer
ISBN:	9783031311826
Funders:	EU H2020 ACDC G.A. n° 82406
Date of First Compliant Deposit:	11 November 2024
Last Modified:	11 Nov 2024 10:04
URI:	https://orca.cardiff.ac.uk/id/eprint/160521

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