Annual short-burst mass anthelmintic administration reduces tuberculosis severity but not prevalence in a wildlife reservoir

Lello, Joanne ORCID: https://orcid.org/0000-0002-2640-1027, Gasso, Diana, Goncalves, Pilar, Risco, David, Garcia, Waldo L., Segale, Joaquim, Garrido-Amaro, Cristina, Mentaberre, Gregorio, Torres-Blas, Irene, Velarde, Roser, Lopez-Olvera, Jorge R., Fernandez-Llario, Pedro and Serrano, Emmanuel 2023. Annual short-burst mass anthelmintic administration reduces tuberculosis severity but not prevalence in a wildlife reservoir. Frontiers in Ecology and Evolution 11 , 1186295. 10.3389/fevo.2023.1186295

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Abstract

Introduction: Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTC), is an important disease in both human and animal systems. Helminths are commonly found in coinfection with MTC and TB is often exacerbated in such coinfections. Long-term anthelmintic administration, to control helminths, can improve a host’s ability to control MTC infection. Mass drug administration programmes, in which anthelmintics are given only once or twice a year, leaving periods where helminth reinfection can occur, are common in both human and domestic animal populations. To date, the effect of such intermittent control programmes on MTC infection and severity has not been explored. Methods: Here we investigate the consequences of a ten-day, annual, mass ivermectin administration on TB prevalence and severity in free-ranging juvenile and yearling (<2 years) wild boar (Sus scrofa). Results: This single annual anthelmintic treatment administered over six years reduced TB severity. Further, the proportion of wild boar with severe TB continued to decrease with successive treatments. TB prevalence, however, did not decrease significantly over the course of the study. Discussion: While ivermectin has direct anti-mycobacterial effects in vitro, the short duration of treatment means that the reduction in TB severity we observe in wild boar is unlikely to be accounted for by such a direct mechanism. Disruption of the helminth community and subsequent modification or enhancement of the host immune response is a potential mechanism. Future work should examine the consequences of annual anthelmintic drug administration on helminth community composition and structure and on the host immunological responses through time.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Frontiers Media
ISSN:	2296-701X
Date of First Compliant Deposit:	23 October 2023
Date of Acceptance:	25 September 2023
Last Modified:	27 Oct 2023 09:45
URI:	https://orca.cardiff.ac.uk/id/eprint/163443

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