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Synthesis and Biological Activities of Novel (3-Methylquinoxalin-2-YL)Hydrazones and Osazones of Aldoses

El-Hiti, Gamal A., Mahgoub, Safa, Abdel-Megeed, Mohamed F. and Mahmoud, Yehia A.-G. 1999. Synthesis and Biological Activities of Novel (3-Methylquinoxalin-2-YL)Hydrazones and Osazones of Aldoses. Delta Journal of Science 23 (1) , pp. 117-130.

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Condensation of equimolar amounts of 2-hydrazino-3- methylquinoxaline (I) and monosaccharides II (D-glucose, Dgalactose, D-xylose, D-arabinose and D-ribose) in boiling ethanol in the presence of glacial acetic acid afforded the corresponding hydrazones III in good yields. However, when the reaction was conducted with three molar equivalents of I the corresponding osazones V was obtained in fair yields. Acetylation of the hydrazones III and osazones V using acetic anhydride in the presence of pyridine at room temperature gave the corresponding acetyl derivatives IV and VI, respectively in excellent yields. The antimicrobial activities of the synthesised compounds were examined against a variety of tested organisms. Some of the synthesised compounds showed antimicrobial activities.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Faculty of Science, University of Tanta
ISSN: 1012-5965
Last Modified: 19 Mar 2016 22:26

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