Risk and timing of venous thromboembolism after surgery for lung cancer: a nationwide cohort study

Mørkved, Amalie Lambert, Søgaard, Mette, Skjøth, Flemming, Ording, Anne Gulbech, Jensen, Martin, Larsen, Torben Bjerregaard, Jakobsen, Erik, Højen, Anette Arbjerg, Noble, Simon ORCID: https://orcid.org/0000-0001-5425-2383, Meldgaard, Peldgaard, Petersen, Rene Horsleben and Christensen, Thomas Decker 2024. Risk and timing of venous thromboembolism after surgery for lung cancer: a nationwide cohort study. The Annals of Thoracic Surgery 117 (2) , pp. 289-296. 10.1016/j.athoracsur.2023.10.015

Full text not available from this repository.

Abstract

Background Venous thromboembolism (VTE) is a potentially preventable serious complication in patients with lung cancer undergoing thoracic operation. We examined the risk and timing of VTE after surgery for primary non-small cell lung cancer (NSCLC). Methods All patients undergoing operation for NSCLC in Denmark between 2003 and 2021 were identified in the Danish Lung Cancer Registry. VTE events in the year after operation were assessed by stage, patient characteristics, and surgical procedure. Results We identified 13,197 patients who underwent operation for NSCLC in 2003 to 2021 (mean age, 67.6 years; 50% female); 10,524 (79.7%) had stage I-II NSCLC, and 2673 (20.3%) had stage III-IV. During 1-year follow-up, there were 335 VTE events, yielding a rate of 2.87 events/100 person-years and an absolute risk of 3.3% (95% CI, 2.3-4.0). VTE risk increased with advancing cancer stage (1.8% for stage I vs 3.9% for stage IV) but varied little by pathologic type, sex, and comorbidity level. Bilobectomy was associated with highest VTE risk (4.8%; 95% CI, 3.2-6.9), followed by pneumonectomy (3.5%; 95% CI, 2.3-5.0). The hazard of VTE was highest during the first 3 months after operation, after which it declined. For stage IV cancer, hazards increased again after 6 months. At 1 year, all-cause death was 12.6% (95% CI, 12.0%-13.1%). Conclusions VTE developed in 3.3% of patients undergoing operation for NSCLC, most commonly within 3 months postoperatively. Prolonged thromboprophylaxis could be considered, particularly in those with advanced cancer stage and undergoing extended resections.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Marie Curie Palliative Care Research Centre (MCPCRC)
Publisher:	Elsevier
ISSN:	0003-4975
Date of Acceptance:	9 October 2023
Last Modified:	15 Jan 2024 13:52
URI:	https://orca.cardiff.ac.uk/id/eprint/164410

Actions (repository staff only)

Edit Item