Death-associated protein 3 in cancer-discrepant roles of DAP3 in tumours and molecular mechanisms

Song, Hao, Liu, Huifang, Wang, Xiufeng, Yang, Yuteng, Zhao, Xiangkun, Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111, Sui, Laijian and Song, Xicheng 2024. Death-associated protein 3 in cancer-discrepant roles of DAP3 in tumours and molecular mechanisms. Frontiers in Oncology 13 , 1323751. 10.3389/fonc.2023.1323751

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

The article has a word count of 4657 as well as contains an image and a table Abstract: Cancer, ranks as the secondary cause of death, is a group of diseases that are characterized by uncontrolled tumor growth and distant metastasis, leading to increased mortality year-on-year. To date, targeted therapy to intercept the aberrant proliferation and invasion is crucial for clinical anticancer treatment, however, mutant expression of target genes often leads to drug resistance. Therefore, it is essential to identify more molecules that can be targeted to facilitate combined therapy. Previous studies showed that death associated protein 3 (DAP3) exerts a pivotal role in regulating apoptosis signaling of tumors, meanwhile, aberrant DAP3 expression is associated with the tumorigenesis and disease progression of various cancers. This review provides an overview of the molecule structure of DAP3 and the discrepant roles played by DAP3 in various types of tumors.Considering the molecular mechanism of DAP3-regulated cancer development, new potential treatment strategies might be developed in the future.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Frontiers Media
ISSN:	2234-943X
Date of First Compliant Deposit:	31 December 2023
Date of Acceptance:	30 December 2023
Last Modified:	14 Feb 2024 14:53
URI:	https://orca.cardiff.ac.uk/id/eprint/165108

Actions (repository staff only)

Edit Item